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| c. 1850 |
| | | The Scottish missionary David Livingstone is profoundly shocked by what he sees of the slave trade at the heart of Africa | |
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| 1850 |
| | | The slave trade, but not slavery itself, is banned in Washington and the district of Columbia | |
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| 1850 |
| | | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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| 1850 |
| | | The US Congress passes the Compromise of 1850, designed to defuse the growing crisis over slavery | |
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| 1850 |
| | | The Fugitive Slave Act, concerned with the arrest of runaway slaves, is the most contentious part of the Compromise of 1850 | |
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| 1850 |
| | | Escaped slave Harriet Tubman makes the first of many dangerous journeys back into Maryland to bring other slaves into freedom | |
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| 1852 |
| | | Harriet Beecher Stowe publishes a massively successful antislavery novel, Uncle Tom's Cabin, that sells 300,000 copies in its first year | |
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| 1854 |
| | | An anti-slavery movement, formed in the USA to oppose the Kansas-Nebraska Act, adopts a resonant name, calling itself the Republican party | |
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| 1854 |
| | | The controversial Kansas-Nebraska Act passes into law, enabling citizens of these territories to decide whether or not to allow slavery | |
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| 1856 |
| | | Abolitionist John Brown presides over the lynching of five pro-slavery men at Pottawatomie in Kansas | |
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